Nathalie Janel Selected Research

Homocystinuria

1/2022	Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse.
10/2018	Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia.
6/2016	Effect of cadmium administration in hyperhomocysteinemic mice due to cystathionine beta synthase deficiency.
2/2015	Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise.
6/2013	Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice.
2/2013	Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice.
8/2009	Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice.
6/2009	Calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor I kappa B alpha.
1/2009	Effect of hyperhomocysteinemia on the protein kinase DYRK1A in liver of mice.
7/2008	Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver.

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Nathalie Janel Research Topics

Disease

36	Hyperhomocysteinemia 01/2022 - 03/2003
16	Homocystinuria 01/2022 - 08/2003
15	Down Syndrome (Down's Syndrome) 06/2022 - 08/2006
7	Cognitive Dysfunction 06/2022 - 02/2013
6	Inflammation (Inflammations) 02/2019 - 05/2005
6	Atherosclerosis 05/2017 - 08/2003
6	Fibrosis (Cirrhosis) 09/2011 - 05/2005
5	Insulin Resistance 01/2022 - 06/2011
5	Cardiovascular Diseases (Cardiovascular Disease) 05/2017 - 01/2011
4	Type 2 Diabetes Mellitus (MODY) 02/2021 - 06/2011
3	Alzheimer Disease (Alzheimer's Disease) 06/2022 - 12/2005
3	Liver Diseases (Liver Disease) 06/2016 - 05/2005
3	Vascular Diseases (Vascular Disease) 10/2006 - 04/2004
2	Intellectual Disability (Idiocy) 05/2022 - 03/2014
2	Metabolic Diseases (Metabolic Disease) 05/2022 - 01/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2018 - 04/2004
2	Hypertrophy 01/2011 - 11/2010
2	Neoplasms (Cancer) 12/2010 - 06/2008
2	Thrombosis (Thrombus) 08/2009 - 08/2003
1	Disease Progression 06/2022
1	Body Weight (Weight, Body) 01/2022
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/2021
1	Alcoholism (Alcohol Abuse) 07/2020
1	Non-alcoholic Fatty Liver Disease 01/2019
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019
1	Amyloid Plaque 01/2019
1	Dyslipidemias (Dyslipidemia) 01/2019
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2016
1	Lung Neoplasms (Lung Cancer) 11/2015
1	Chronic Kidney Failure (Chronic Renal Failure) 03/2015
1	Memory Disorders (Memory Loss) 01/2015
1	Hyperinsulinism (Hyperinsulinemia) 01/2014
1	Brain Diseases (Brain Disorder) 02/2013
1	Trisomy (Trisomies) 10/2012
1	Aneuploidy (Aneuploid) 10/2012

Drug/Important Bio-Agent (IBA)

24	Cystathionine beta-Synthase (Serine Sulfhydrase)IBA 01/2022 - 03/2003
23	HomocysteineIBA 01/2022 - 03/2003
9	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 06/2022 - 11/2010
8	Proteins (Proteins, Gene)FDA Link 06/2022 - 05/2005
7	Aryldialkylphosphatase (Paraoxonase)IBA 03/2015 - 08/2003
6	Biomarkers (Surrogate Marker)IBA 06/2022 - 08/2009
6	CytokinesIBA 01/2019 - 05/2005
6	EnzymesIBA 06/2016 - 01/2007
6	Methionine (L-Methionine)FDA Link 03/2015 - 01/2009
5	Phosphotransferases (Kinase)IBA 01/2019 - 10/2009
4	Catechin (Z 7300)IBA 05/2022 - 03/2007
4	XenobioticsIBA 06/2016 - 06/2008
4	PolyphenolsIBA 04/2013 - 01/2009
3	FlavonoidsIBA 05/2022 - 03/2007
3	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 02/2020 - 02/2014
3	AdenosylhomocysteinaseIBA 05/2017 - 10/2009
3	Biological ProductsIBA 05/2013 - 08/2009
3	Transforming Growth Factor beta1 (TGF beta 1)IBA 01/2011 - 05/2005
2	Protein Kinases (Protein Kinase)IBA 05/2022 - 01/2009
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2014
2	TeaIBA 01/2019 - 07/2016
2	Insulin (Novolin)FDA Link 01/2019 - 01/2014
2	NAD (NADH)IBA 05/2017 - 10/2009
2	quinone (benzoquinone)IBA 05/2017 - 10/2009
2	Drinking WaterIBA 06/2016 - 08/2009
2	Apolipoprotein A-I (Apolipoprotein A1)IBA 03/2015 - 11/2013
2	Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)IBA 03/2015 - 11/2013
2	N-acetyltalosaminuronic acid (NAT)IBA 08/2011 - 12/2010
2	Oxidoreductases (Dehydrogenase)IBA 10/2009 - 08/2007
2	CalpainIBA 06/2009 - 01/2009
2	Sulfhydryl Compounds (Thiols)IBA 01/2009 - 10/2006
2	CholesterolIBA 07/2008 - 01/2007
2	alpha 1 Chain Collagen Type IIBA 10/2007 - 05/2005
2	Complementary DNA (cDNA)IBA 04/2004 - 08/2003
1	Proline (L-Proline)FDA Link 06/2022
1	CystathionineIBA 01/2022
1	Pharmaceutical PreparationsIBA 02/2021
1	Ethanol (Ethyl Alcohol)IBA 07/2020
1	calpastatinIBA 02/2019
1	LipopolysaccharidesIBA 02/2019
1	CeramidesIBA 01/2019
1	Amyloid (Amyloid Fibrils)IBA 01/2019
1	Interleukin-12 (IL 12)IBA 01/2019
1	Tyrosine (L-Tyrosine)FDA Link 01/2019
1	LycopeneIBA 06/2016
1	CadmiumIBA 06/2016
1	Heavy MetalsIBA 06/2016
1	IronIBA 11/2015
1	Environmental Pollutants (Pollutants, Environmental)IBA 11/2015
1	Particulate MatterIBA 11/2015
1	VitaminsIBA 03/2015
1	Alanine Transaminase (SGPT)IBA 03/2015
1	GABA Receptors (GABA Receptor)IBA 01/2015
1	Dyrk KinasesIBA 03/2014
1	HDL LipoproteinsIBA 11/2013
1	Lipoproteins (Lipoprotein)IBA 11/2013
1	Vitamin B Complex (B Vitamins)IBA 06/2013
1	NitratesIBA 06/2013
1	S-Adenosylmethionine (Ademetionine)IBA 05/2013
1	AntioxidantsIBA 04/2013
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 02/2013
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 10/2012

Therapy/Procedure

1	Intraperitoneal Injections 01/2019
1	Cognitive Training 07/2016
1	Therapeutics 03/2015